Pathology

The Pathology Laboratory at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute offers anatomic and clinical pathology services to research scientists, investigators, veterinarians and physicians at Texas Biomed and other research facilities.

Our ACVP board-certified pathologists – Edward J. Dick, Jr., D.V.M., dACVP, Olga Gonzalez, D.V.M., dACVP and Vinay Shivanna D.V.M, MVSc, PhD, dACVP, dACVM – are available to discuss laboratory results, research protocols and consult on difficult clinical cases.

What we offer

Necropsy procedures of primate or other species. We collect case or study specific tissues utilizing multiple techniques such as fresh, fixed, frozen, and sterile media. New methodologies can be developed upon request.
Histopathology, including cytopathology, OCT embedding, cryosectioning, multiplex immunohistochemistry, and RNAScope (in situ hybridization). Diagnostic interpretation, tissue scoring, microscopic evaluation, and imaging and stereological evaluation of tissue samples by board-certified veterinary pathologists.
Chemistry, hematology, and coagulation testing are performed on state-of-the-art instrumentation by our ASCP certified medical technologists who have over 77 years combined experience in the laboratory field.
Daily quality control monitoring and quality assurance programs.
Statistically relevant reference intervals for colony-specific species including baboons, chimpanzees, macaques, and marmosets.
Customized profiles:
- Sophisticated serum banking system with archived sample.
- Referral testing – referrals are sent to national accredited laboratories for diagnostic and research testing when in-house testing is not performed
SNPRC Diagnostic Microbiology Lab
SNPRC diagnostic microbiology lab provides diagnostic microbiology support to Non-human primate colonies at SNPRC. It is involved in development, validation, and application of molecular diagnostic methods to detect and characterize various pathogens associated with clinical illness in nonhuman primate colonies. Developed assays are used to detect and characterize pathogens in clinical samples from NHP colonies and also as a screening assay for animal health assessment before the sale or purchase of animals at SNPRC.

Following PCR assays are available to detect pathogens in clinical samples:

Sl no.	Tests and targets	Name of the test	Type of sample
1	PCR to detect Escherichia. coli	E. coli PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
2	PCR to detect Salmonella	Salmonella PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
3	PCR to detect Shigella	Shigella PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
4	PCR to detect Campylobacter jejuni	C. jejuni PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
5	PCR to detect Campylobacter coli	C. coli PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
6	Multiplex PCR to characterize E. coli Enteropathogenic/Enterohemorrhagic/Shigatoxigenic E. coli	E. coli characterization PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
7	PCR to detect Pseudomonas aeruginosa	P. aeruginosa PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE
8	PCR to detect baboon specific Simian Adenovirus	AdenovirusPCR	Nasopharyngeal swab
9	Duplex PCR to detect and characterize Yersinia enterolitica	Y. enterocolitica PCR	Rectal/Fecal swab/fresh fecal sample/tissue/FFPE

*FFPE – Formalin Fixed Paraffin embedded tissues

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